NATURAL PRODUCT INSPIRED SYNTHESIS
Projects in the Beeler Group are focused on synthesis and medicinal chemistry of biologically active small molecules. We focus on developing efficient and scalable processes to synthesize scaffolds of interest. We select molecules that we believe may be optimized as powerful tools to better understand biological processes important to human health. Ultimately, these tools can serve to identify new therapeutic targets or even be lead molecules for future therapeutics. Current projects in the group are focused on molecules that have demonstrated neuroprotective activity, modulate the immune system, or are cytotoxic to cancer cells.
This area focuses on photochemical transformations toward the synthesis of natural products, natural product scaffolds, and other complex chemotypes of interest to medicinal chemistry and chemical biology. The foundation of these projects is utilizing microfluidics to enable photochemical reaction development.
One of the core components in our research is development of continuous flow technologies to facilitate the synthesis and medicinal chemistry of target molecules. Flow chemistry has emerged as a powerful tool to enable reactions that have traditionally been challenging to carry our and/or difficult to scale. We are utilizing flow technologies to develop photochemical reactions, electrochemical reactions, and reactions utilizing highly reactive intermediates. The methods we develop are applied to the synthesis of molecules for medicinal chemistry.